Spatial and Temporal Patterns of Global H5n1 Outbreaks

The global spread of highly pathogenic avian influenza (H5N1) in wild birds and poultry is considered a significant pandemic threat. Furthermore, human infections resulting from direct contact with infected birds/poultry pose a serious public health threat. From November 2003 to March 2007, a total of 3345 H5N1 outbreaks were reported worldwide. Spatial and temporal patterns can provide clues in understanding the dynamics of disease spread. However, little has been done to explore these patterns of H5N1 outbreaks during this period at the global scale. The objective of this research is to detect spatial, temporal and space-time clustering using geostatistical methods. Data from histological confirmed cases of H5N1were obtained from a Dutch web site and a Google earth data. Kernel estimation, G and F functions were used to test the first-order and the second-order spatial clustering respectively. An autocorrelation function and a periodogram were used to detect the temporal clustering. In addition, Knox’s test, space-time Kfunction and space-time scan statistics were used to explore the space-time clustering. The Monte Carlo simulation was used to test the significance of the clustering. Examination of spatial and temporal patterns indicates significant spatial clustering and seasonal cyclicity. The Monte Carlo test revealed strong evidence for space-time clustering of H5N1 cases and the location of significant space-time clusters were detected. The results are considered to be valuable for global H5N1 surveillance, prevention and possible future outbreaks controlling. * Corresponding author